Vella Lab label

Mission Trajectory

The Vella Lab seeks to advance human immune health through clinical and translational immunology. Our work focuses on understanding human CD4+ T cell states and CD4+ T follicular helper (Tfh) biology to advance basic understanding of human immunity and to directly change the ways in which we can measure and modulate human T-B interactions.

Working directly with clinical cohorts, we investigate how T cell programs are established, dysregulated, or reconstituted in vaccination, infection, and inflammatory diseases. We also study the mechanisms regulating Tfh differentiation and germinal center biology, applying the discoveries to understand T-B cell interaction across clinical contexts.

Our approaches require innovative single-cell technologies and computational analyses. In addition to studying the host cell, we also study viral integration events in those cells, applied to the fields of HIV reservoir and lentiviral-modified cellular therapies. In these approaches we aim to link viral or therapeutic gene integration with cellular phenotyping to uncover mechanisms of HIV persistence, determinants of CAR-T cell function, and the effects of gene-editing on immune cell recovery in genetic diseases.

By integrating clinically-relevant research, human immunology, and technological innovation, our mission is to advance precision immunology to uncover the cellular mechanisms that shape protective immunity and inform next-generation immune therapies.

News

March 2026

๐ŸŽ™๏ธ Sam attends the Keystone Symposium on B and T Cell Collaboration in Lymphoid and Nonlymphoid Microenvironments, with the NIAID-funded Keystone Symposia Scholarship.

๐Ÿบ Sam is awarded the Mary Ellis Bell Prize for his paper.

February 2026

๐Ÿ“ Leena submits her paper โ€” congratulations!

๐ŸŽ™๏ธ Yi attends CROI 2026 and receives the New Investigator Scholarship.

January 2026

๐ŸŒŽ We welcome Davi Nunes as the lab’s third Researcher of the Future.

๐Ÿ”ฌ We welcome our newest IGG rotation student, Kaila Powell.

December 2025

๐ŸŽ™๏ธ Kingsley, Leena, and Ben attend the 2025 ASH Annual Meeting.

๐Ÿ“ Sam submits his paper โ€” congratulations!

September 2025

๐Ÿ’ We celebrate our second lab wedding โ€” congratulations to Sam & Lydia!

๐Ÿ“Œ Nosa presents a poster at the Fall Research Expo.

July 2025

๐ŸŒŸ Hunter Courtney completes his time in the lab and heads to the MSTP program at UCLA and Caltech.

June 2025

๐Ÿ‘ถ Kingsley becomes a new dad โ€” our first lab baby!

๐ŸŽค The team attends and presents at the CHOP I2DRI Scientific Symposium.

May 2025

๐Ÿฅ‚ Katie passes her preliminary exam.

January 2025

๐ŸŒ We welcome Brazilian student Aisha Zhogbi as our second Researcher of the Future.

November 2024

๐ŸŽŠ After a successful rotation, Katie Premo officially joins the team.

October 2024

๐Ÿ Penn FERBS member Nosamudiana Omoigui joins the lab.

September 2024

๐Ÿ’ We celebrate our first lab wedding โ€” congratulations to Kingsley & Shavonda!

๐Ÿ™Œ Monica Manglani, a Rheumatology fellow at CHOP, joins the lab.

๐Ÿ‘ฉโ€๐Ÿ”ฌ Molly moves on to become a medical lab scientist in the Department of Pathology and Laboratory Medicine at CHOP.

July 2024

๐ŸŒŸ Ben Philipson, a CHOP Hematology/Oncology fellow, joins the Vella Lab.

June 2024

๐Ÿซ We welcome Atoishy Dayve, our first undergraduate volunteer from Drexel University.

March 2024

๐Ÿ“ Kingsley submits a paper to The Journal of Infectious Diseases.

January 2024

๐ŸŒŽ The lab participates in the inaugural CHOP Researchers of the Future program, welcoming Carol Ferraz from Brazil.

November 2023

๐Ÿฉบ MSTP (IGG) student Sam Barnett Dubensky joins the Vella Lab, co-mentored by Derek Oldridge.

September 2023

๐Ÿ‚ IGG students Oishi Bardhan and Katie Premo start their rotations in the lab.

August 2023

๐Ÿ’ป Tianyu Lu joins as the lab’s first bioinformatician.

๐Ÿš€ Our very first employee, Shane Kammerman, moves to Massachusetts to join Candel Therapeutics.

June 2023

๐Ÿงช Yi Qi joins the Vella Lab from Penn Bioengineering.

May 2023

๐Ÿพ Nina de Luna and Leena Babiker both pass their preliminary exams.

๐Ÿ’ซ Josef Novacek departs the lab to pursue studies in patent law.

February 2023

๐Ÿ‡ฉ๐Ÿ‡ช We welcome Emilia Schlaak from Germany, the lab’s first international volunteer student.

January 2023

๐ŸŒฑ IGG student Nicolai Apenes rotates in the lab.

September 2022

๐Ÿงฌ Research Technician and single-cell expert Molly Gallagher joins the lab.

May 2022

๐Ÿ” Austin Kriews becomes the first BBCB graduate student to rotate in the lab.

December 2021

๐ŸŽ‰ Hunter Courtney becomes the first Penn undergraduate to volunteer in the lab.

October 2021

โœจ For the first time, two IGG students rotate in the lab at once: Nina de Luna and Leena Babiker.

September 2021

๐Ÿ“ฆ The lab relocates from UPenn’s BRB II/III to the new 10th floor of CHOP CTRB.

๐Ÿ˜Ž We welcome our first postdoctoral fellow, Kingsley Kumashie.

August 2021

๐ŸŒŸ Josef Novacek joins the lab as our third employee.

June 2021

๐Ÿ™Œ We welcome our second team member and lab manager, Jonny Tedesco.

January 2021

๐Ÿ”ฌ Julia Eberhard becomes the first IGG graduate student to rotate in the lab.

July 2020

1๏ธโƒฃ The Vella Lab officially begins virtually (COVID ๐Ÿ˜…), and we welcome our very first team member, Shane Kammerman.